Python can be used to create desktop applications with graphical user interfaces (GUIs) using various libraries and frameworks. 

Here’s a step-by-step guide to creating desktop applications using Python:

Choose a GUI Framework:
Decide on the GUI framework you want to use. Some popular options include:
Tkinter: Python’s built-in GUI library, simple and lightweight.
PyQt: A widely-used library that provides a set of Python bindings for the Qt application framework.
wxPython: A library that wraps the native GUI libraries of each platform (Windows, macOS, Linux).
Kivy: A cross-platform Python framework for developing multi-touch applications.

Install the Framework:

Install the chosen GUI framework using pip or follow the installation instructions provided by the framework’s documentation.

Design the GUI:

Design the graphical user interface of your application using the provided tools or by writing code. Create windows, buttons, labels, text fields, and other interface components.

Event Handling:

Define how your application should respond to user interactions (button clicks, menu selections, etc.). Attach event handlers to GUI components.

Layout Management:

Use layout managers provided by the framework to arrange components on the window. This ensures your interface adapts well to different screen sizes and orientations.

Adding Functionality:

Implement the functionality of your application. This could involve reading/writing files, data processing, connecting to APIs, or any other desired feature.

Testing and Debugging:

Test your application thoroughly to identify and fix bugs. Use debugging tools provided by your IDE or framework.

Packaging:

Package your application into an executable or installer that users can easily install and run on their systems. Depending on the framework, there are tools that can help with this process.

Deployment:

Distribute your application to users. Consider the target platform (Windows, macOS, Linux) and ensure your application works seamlessly on each.

User Documentation:

Create user documentation to guide users on how to install and use your application.

Continuous Improvement:

Collect user feedback and make improvements to your application based on their suggestions or identified issues.

Advanced Features (Optional):

Depending on your application’s complexity, consider adding features like internationalization, theming, data persistence, or integration with external services.

Community and Resources:

Join relevant online communities, forums, and tutorials related to your chosen GUI framework to learn from others and solve challenges.

Remember that creating desktop applications involves both coding and design aspects. Start with simple projects to become familiar with the chosen framework, and gradually work your way up to more complex applications.